MRI screening of kindred at risk of developing paragangliomas : support for genomic imprinting in hereditary glomus tumours.
Paragangliomas of the head and neck (glomus tumours) can occur in a hereditary pattern and may be hormonally active as well as being associated with paragangliomas elsewhere.
A number of these tumours may be present without symptoms.
To detect the presence of subclinical paragangliomas we screened 83 members of a family at risk of developing hereditary paragangliomas using whole body MRI and urinary catecholamine testing.
In eight previously diagnosed members, eight known glomus tumors of which one functioning, and two unknown glomus tumours and one unknown pheochromocytoma were present.
Mots-clés Pascal : Paragangliome, Tête cou, Facteur risque, Imagerie RMN, Exploration, Dépistage, Diagnostic, Tumeur glomique, Maladie héréditaire, ORL pathologie, Système nerveux pathologie, Tumeur, Enfant, Homme, Empreinte génétique
Mots-clés Pascal anglais : Paraganglioma, Head and neck, Risk factor, Nuclear magnetic resonance imaging, Exploration, Medical screening, Diagnosis, Glomus tumor, Genetic disease, ENT disease, Nervous system diseases, Tumor, Child, Human, Genomic imprinting
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 92-0458397
Code Inist : 002B10A01. Création : 199406.