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  1. A method for quantitative assessment of reproductive risks to the human male.

    Article - En anglais

    There is a need for quantitative assessment of reproductive risks following human exposure to toxic agents.

    Current methods only estimate exposure levels that are unlikely to produce appreciable risk; they do not address the magnitude of risk.

    The quantitative reproductive risk estimation (QRRE) approach presented here enables calculation of the increased incidence of infertility in a human population resulting from exposure of males to a toxic agent.

    The four steps involve (A) obtaining a dose-response curve in experimental animals for the effect of a toxicant on a measure of reproductive function.

    Mots-clés Pascal : Composé chimique, Toxicité, Reproduction pathologie, Appareil génital mâle pathologie, Homme, Evaluation, Risque, Méthode étude, Animal, Stérilité

    Mots-clés Pascal anglais : Chemical compound, Toxicity, Reproduction diseases, Male genital diseases, Human, Evaluation, Risk, Investigation method, Animal, Sterility

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 92-0404835

    Code Inist : 002B03A. Création : 199406.