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  1. The dynamics of drug resistance in Plasmodium falciparum.

    Article - En anglais

    Drug resistance of Plasmodium falciparum is not a recent phenomenon, but it became a major problem when the parasite became resistant to chloroquine, the cheapest and initially the most effective antimalarial compound that could be used for treatment and suppression.

    In some areas this problem is compounded by resistance to the first line of alternative drugs, and rapid loss of sensitivity to the next line.

    The dynamics of drug resistance are regulated mainly by drug related selection pressure and intensity of malaria transmission.

    Mots-clés Pascal : Antipaludique, Antiparasitaire, Mécanisme, Résistance, Plasmodium falciparum, Sporozoa, Protozoa, Epidémiologie, Sensibilité résistance, Homme, Paludisme, Protozoose, Infection, Répartition géographique, Article synthèse

    Mots-clés Pascal anglais : Antimalarial, Parasiticid, Mechanism, Resistance, Plasmodium falciparum, Sporozoa, Protozoa, Epidemiology, Sensitivity resistance, Human, Malaria, Protozoal disease, Infection, Geographic distribution, Review

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 92-0682196

    Code Inist : 002B02S06. Création : 199406.