DNA instability, paternal irradiation and leukaemia in children around sellafield.
The chemical instability of DNA under physiological conditions requires that cells have highly developed processes for repairing stochastic single-strand damage.
It is proposed here that provided ionizing-radiation-induced single-strand damage does not occur at a rate sufficient to perturb the dynamic steadystate between degradation and repair, it can be regarded as 'irrelevant' to biological effect, leaving double-strand damage and DNA-protein crosslinks as 'relevant' damage to biological effect.
Mots-clés Pascal : Radiocontamination, Irradiation ionisante, Risque, Leucémie, Hémopathie maligne, Père, Lignée germinale, Radiolésion, DNA, Spermatogenèse, Mutation, Radiobiologie, Biophysique, Sellafield
Mots-clés Pascal anglais : Radioactive contamination, Ionizing irradiation, Risk, Leukemia, Malignant hemopathy, Father, Germ line, Radiation injury, DNA, Spermatogenesis, Mutation, Radiobiology, Biophysics
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 92-0245471
Code Inist : 002A08F03. Création : 199406.