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  1. Multiple recombination events are responsible for the heterogeneity of alpha+-thalassemia haplotypes among the forest tribes of Andhra Pradesh, India.

    Article - En anglais

    The presence of several polymorphic markers along the alpha-globin gene complex allows the identification of haplotypes associated with alpha-thalassemia determinants.

    These are found at very high frequencies in geographic areas where malaria is or has been endemic which suggests a positive selective role by the parasitic disease in favour of alpha+-thalassemia mutants.

    A population survey among forest tribal communities from Andhra Pradesh, India, revealed the prevalence and molecular heterogeneity of alpha+-thalassemia determinants presumably due to a long backdated malaria endemicity among these populations.

    Mots-clés Pascal : Asie, Thalassémie alpha, Hémoglobinopathie, Inde, Hémopathie, Allèle, Haplotype, Polymorphisme longueur fragment restriction, Epidémiologie, Fréquence génique, Homme, Globine, Gène, Biologie moléculaire, Génétique

    Mots-clés Pascal anglais : Asia, alpha-Thalassemia, Hemoglobinopathy, India, Hemopathy, Allele, Haplotype, Restriction fragment length polymorphism, Epidemiology, Gene frequency, Human, Globin, Gene, Molecular biology, Genetics

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 91-0506560

    Code Inist : 002B19A01. Création : 199406.