A complex segregation analysis was conducted on two British series (one consecutive series of probands with breast cancer and one series ascertained through a normal consultand).
Altogether there were 1248 nuclear families with breast cancer.
A dominant gene with a frequency of 0.003 giving a lifetime penetrance of 0.83 is favoured.
Ovarian, endometrial and cancers associated with the SBLA syndrome, as well as benign breast disease, were significantly more common in familial breast cancer than in families of single cases.
Mots-clés Pascal : Royaume Uni, Europe, Glande mammaire, Grande Bretagne, Tumeur, Glande mammaire pathologie, Epidémiologie, Homme, Etude familiale, Analyse ségrégation
Mots-clés Pascal anglais : United Kingdom, Europe, Mammary gland, Great britain, Tumor, Mammary gland diseases, Epidemiology, Human, Family study, Segregation analysis
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 91-0501364
Code Inist : 002B20E02. Création : 199406.