logo BDSP

Base documentaire

  1. Case-control studies of environmental influences in diseases with genetic determinants, with an application to Alzheimer's disease.

    Article - En anglais

    Many diseases have both genetic and environmental determinants.

    Some require both, and the disease phenotype then appears only when a vulnerable genotype is expressed after interaction with environmental factors.

    The detection of such environmental factors has received little prior consideration in diseases with genetic causes.

    In particular, case-control studies of such diseases may compare exposures among cases, who have the susceptible genotype, and controls who mostly lack it.

    The authors explored the likely results of such studies, using the example of Alzheimer's disease as an illness where environmental factors may interact with a necessary susceptible genotype to accelerate disease expression.

    Mots-clés Pascal : Démence Alzheimer, Epidémiologie, Facteur risque, Facteur milieu, Génotype, Déterminisme génétique, Analyse statistique, Homme, Maladie dégénérative, Système nerveux pathologie

    Mots-clés Pascal anglais : Alzheimer disease, Epidemiology, Risk factor, Environmental factor, Genotype, Inheritance, Statistical analysis, Human, Degenerative disease, Nervous system diseases

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 91-0477897

    Code Inist : 002B17G. Création : 199406.