Measures of the effects of vaccination in a randomly mixing population.
Vaccine efficacy in the field is often derived from the relative attack rates in the vaccinated and unvaccinated after an outbreak.
In this paper, vaccine efficacy is defined in terms of the probability that the infectious agent is transmitted from an infected to a susceptible person, and a method for estimating it from the usual attack rate data is given.
We explore two mechanisms of vaccine action defined by Smith et al, but include an underlying dynamic epidemic model of an acute directly transmitted disease.
Mots-clés Pascal : Epidémiologie, Vaccination, Infection, Transmission, Modèle mathématique, Probabilité, Etude théorique, Méthodologie
Mots-clés Pascal anglais : Epidemiology, Vaccination, Infection, Transmission, Mathematical model, Probability, Theoretical study, Methodology
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 91-0463273
Code Inist : 002B30A. Création : 199406.