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  1. The prospects of the development of the method for monitoring of occupational exposure to some alkylating agents.

    Article - En anglais

    DNA-adduct formation, depurination and imidazole ringopening were followed in vitro using styrene oxide, ethyleneimine and dimethyl sulfate.

    Depurination was found to be about 50 times faster in nucleosides than in double-stranded DNA.

    This apparent discrepancy in depurination between alkylated and intact bases suggests the possibility of developing a sensitive method for monitoring of DNA alkylations formed by electrophillic chemicals, which might be based on labelling of apurinic sites and utilized for in vivo studies as well.

    Mots-clés Pascal : Exposition professionnelle, Hygiène, Carcinogène, Dépurination, Alkylation, DNA, Xénobiotique, Contrôle, Méthodologie

    Mots-clés Pascal anglais : Occupational exposure, Hygiene, Carcinogen, Depurination, Alkylation, DNA, Xenobiotic, Check, Methodology

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 91-0237563

    Code Inist : 001D16C06. Création : 199406.