Population genetics of colonic cancer.
National conference on integration of molecular genetics into cancer management. Miami FL (USA), 1991/04/10.
There are several well known but rare syndromes of inherited colonic cancer.
Genetic epidemiologic studies also have demonstrated that relatives of individuals with colonic cancer in general exhibit an excess risk for this malignancy.
This report reviews the literature pertinent to genetic and familial risk for colonic cancer with emphasis on the recent work that suggests that inherited susceptibility to colonic neoplasms is common, Results.
The adenomatous polyposis syndromes are rare inherited colonic cancer conditions caused by a mutant gene which recently has been characterized.
Hereditary nonpolyposis colorectal cancer is likewise inherited and may account for up to 5% of cases.
The molecular genetics of this disease remain to be clarified.
Mots-clés Pascal : Tumeur maligne, Polype adénomateux, Adénome, Côlon, Rectum, Intestin pathologie, Appareil digestif pathologie, Maladie héréditaire, Génétique population, Déterminisme génétique, Etude familiale, Epidémiologie, Tumeur bénigne, Homme
Mots-clés Pascal anglais : Malignant tumor, Adenomatous polyp, Adenoma, Colon, Rectum, Intestinal disease, Digestive diseases, Genetic disease, Population genetics, Inheritance, Family study, Epidemiology, Benign neoplasm, Human
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 93-0624424
Code Inist : 002B13B01. Création : 199406.