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  1. Ingestion of carcinogenic N-nitrosamines by infants and children.

    Article - En anglais

    Up to one-third of the nitrosamines present in a rubber nipple may migrate into the milk in the bottle within a few hours.

    Transfer into infant formula may exceed 40%, and transfer into saliva may be even higher.

    Thus, a highly contaminated nipple may cause a 5-kg infant who drinks 1 l/d to ingest approximately 2 mug/kg body weight d of nitrosamines.

    To this, add any exposure resulting from pacifier use or from in vivo nitrosation of precursors.

    Therefore, daily exposure of infants may, in the worst case, conceivably reach 4-5 mug/kg body weight d. Entire average daily exposure of an American adult to volatile nitrosamines from major sources is estimated to be less than 0.05 mug/kg body weight d. Infants who use products like those tested may, therefore, be exposed daily to <=100 times more of these carcinogens than are adults.

    In countries where appropriate legislation has yet to be enacted or adequately enforced, these products may represent both a major source of exposure to potent carcinogens of children and, given the increased sensitivity of newborns to carcinogens, a most serious public health hazard.

    Mots-clés Pascal : Homme, Nitrosamine, Carcinogène, Analyse, Teneur, Caoutchouc, Exposition, Epidémiologie, Enfant, Nourrisson, Nouveau né, Voie orale, Législation, Toxicité, Tétine, Sucette, Biberon

    Mots-clés Pascal anglais : Human, Nitrosamine, Carcinogen, Analysis, Content, Rubber, Exposure, Epidemiology, Child, Infant, Newborn, Oral administration, Legislation, Toxicity

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 91-0480304

    Code Inist : 002B04E02. Création : 199406.