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  1. Spontaneous mutation in familial adenomatous polyposis.

    Article - En anglais

    A retrospective review of the familial adenomatous polyposis registry at the Cleveland Clinic Foundation revealed an incidence of spontaneous mutation in familial adenomatous polyposis (FAP) of 22 percent of family kindreds.

    These patients were reviewed retrospectively and compared with the total FAP population followed at The Cleveland Clinic Foundation with respect to the onset of disease, the incidence of carcinoma in the resected colon, and incidence of extracolonic manifestations.

    Review of the characteristics and presentations of these patients suggested that these individuals may harbor a more severe form of FAP.

    Mots-clés Pascal : Polype, Etude familiale, Mutation, Spontané, Tumeur, Maladie héréditaire, Appareil digestif pathologie, Côlon, Epidémiologie, Homme

    Mots-clés Pascal anglais : Polyp, Family study, Mutation, Spontaneous, Tumor, Genetic disease, Digestive diseases, Colon, Epidemiology, Human

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 91-0117566

    Code Inist : 002B13B01. Création : 199406.