Organic and mineral components of bone from the vertebral bodies of an individual with occupational exposure to plutonium were separated by four techniques.All samples were subjected to radiochemical analysis for 239+240Pu.
Nearly all of the total skeletal plutonium was associated with the mineral bone.
Approximately 3% of the skeletal plutonium was estimated to be resident in the marrow.
This suggests that the dose to the mineralised portion of the bone and closely associated cells, may be an order of magnitude or more greater than the dose to the red marrow, resulting in a several fold greater risk from bone tumorigenesis than leukaemias when the relative risk per unit dose is factored in.
Mots-clés Pascal : Plutonium, Os, Squelette, Toxicocinétique, Exposition professionnelle, Médecine travail, Moelle osseuse, Distribution, Elément minéral, Composé organique, Homme, Système ostéoarticulaire, Radioisotope, Toxicologie, Radiobiologie, Biophysique
Mots-clés Pascal anglais : Plutonium, Bone, Skeleton, Toxicokinetics, Occupational exposure, Occupational medicine, Bone marrow, Distribution, Inorganic element, Organic compounds, Human, Osteoarticular system, Radioisotope, Toxicology, Radiobiology, Biophysics
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 91-0115711
Code Inist : 002B03L05. Création : 199406.