A warfarin-resistant strain of rats trapped in Chicago was studied to determine the mechanism of the warfarin resistance.
The Chicago-resistant rats (CR) differ from a Welsh-resistant strain (WR) which has a vitamin K epoxide reductase that is insensitive to warfarin.
The epoxide and dithiol-dependent quinone reductases of the CR rats were as sensitive to warfarin as the normal enzyme.
Unlike the irreversible warfarin inhibition seen in normal rats, the warfarin inhibition of the epoxide reductase from the CR strain was partially reversible in vitro.
In this respect, the CR rats appeared similar to a Scottish warfarin-resistant strain.
Mots-clés Pascal : Rodentia, Mammalia, Vertebrata, Warfarine, Rodenticide, Sensibilité résistance, Spécificité souche, Mécanisme action, Rat, Anticoagulant, Enzyme, Microsome, Foie, Animal, Appareil digestif, Vitamin-K-epoxide reductase(warfarin-sensitive), Vitamin-K-epoxide reductase(warfarin-insensitive)
Mots-clés Pascal anglais : Rodentia, Mammalia, Vertebrata, Rodenticide, Sensitivity resistance, Strain specificity, Mechanism of action, Rat, Anticoagulant, Enzyme, Microsome, Liver, Animal, Digestive system, Vitamin-K-epoxide reductase(warfarin-sensitive), Vitamin-K-epoxide reductase(warfarin-insensitive)
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 91-0086526
Code Inist : 002B30E. Création : 199406.