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  1. Risk assessment of carcinogenic and noncarcinogenic chemicals.

    Article - En anglais

    The science of toxicology focuses on identifying potential hazards to human health using surrogate animal studies.

    Margins of Safety and establishment of ADIs (Acceptable Daily Intakes) are methods applied to animal test data to set « safe » levels of potential exposure.

    Quantitative Risk Assessment (QRA) methods using mathematical models have been advanced to extrapolate from animal exposures.

    The present manuscript considers both methods for evaluation of chemical safety and focuses on the scientific merits and limitations of each.

    Mots-clés Pascal : Composé chimique, Carcinogène, Evaluation, Risque, Homme, Extrapolation animal homme, Comparaison interspécifique, Comparaison intraspécifique, Méthode étude, Réglementation, Modèle mathématique, Toxicité, Article synthèse

    Mots-clés Pascal anglais : Chemical compound, Carcinogen, Evaluation, Risk, Human, Man animal extrapolation, Interspecific comparison, Intraspecific comparison, Investigation method, Regulation, Mathematical model, Toxicity, Review

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 91-0034619

    Code Inist : 002B04E02. Création : 199406.