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  1. Tetracycline in uranyl nitrate intoxication: its action on renal damage and U retention in bone.

    Article - En anglais

    In acute intoxication, uranium (U) not only inhibits bone formation but its excretion in urine also causes renal damage.

    The former effect is ameliorated by tetracycline (TC), probably due to its chelation property, which might also prevent U deposition in bone.

    Chemical determination of U incorporated in bone and a histological study of the kidneys were performed on animals injected with U and then treated with TC.

    The results showed that TC was unable to prevent the binding of U to bone while it exacerbated U-induced renal damage.

    Mots-clés Pascal : Rodentia, Mammalia, Vertebrata, Tétracycline dérivé, Uranium, Toxicité, Rein, Os, Intoxication, Voie intrapéritonéale, Traitement, Chimiothérapie, Radioisotope, Composé marqué, Uranyle Nitrate, Pathologie expérimentale, Animal, Rat, Radiolésion, Appareil urinaire pathologie, Système ostéoarticulaire pathologie, Radiobiologie, Biophysique, Antibiotique, Médecine travail, Uranium 238

    Mots-clés Pascal anglais : Rodentia, Mammalia, Vertebrata, Tetracycline derivatives, Uranium, Toxicity, Kidney, Bone, Poisoning, Intraperitoneal administration, Treatment, Chemotherapy, Radioisotope, Labelled compound, Uranyl Nitrates, Experimental disease, Animal, Rat, Radiation injury, Urinary system disease, Diseases of the osteoarticular system, Radiobiology, Biophysics, Antibiotic, Occupational medicine

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 91-0122937

    Code Inist : 002B03L05. Création : 199406.