We report a series of 24 health-care workers with respiratory symptoms suggestive of occupational asthma due to glutaraldehyde exposure.
The history of asthmatic symptoms was investigated with peak expiratory flow rate (PEFR) monitoring, and in eight of the subjects, the specific bronchial provocation test (SBPT) was applied as reference standard for diagnosis of occupational asthma.
Levels of glutaraldehyde were monitored in the challenge chamber during the SBPT.
Work environmental levels of glutaraldehyde were measured from air samples collected at least once during the PEFR monitoring of endoscopy and theatre nurses.
Specific IgE antibodies to glutaraldehyde were measured with a series of glutaraldehyde modified proteins.
In the eight workers who underwent SBPT, the diagnosis of occupational asthma was confirmed by a positive reaction (late and dual reaction in five and in three subjects, respectively).
The mean level of glutaraldehyde observed during the challenge tests was 0.075 mg/m3 (range 0.065-0.084 mg/m3).
In 13 out of the 16 remaining workers, the serial PEFR monitoring showed a work-related effect.
In three workers, there was no physiological confirmation of occupational asthma.
Levels of glutaraldehyde from the air samples collected in the workplace were as follows : personal short-term samples (mean 0.208 mg/m3 ; median 0.14 mg/m3 ; range 0.06-0.84 mg/m3), personal long-term samples.
(mean 0.071 mg/m3 ; median 0. (...)
Mots-clés Pascal : Glutaral, Antiseptique, Désinfectant, Exposition professionnelle, Milieu hospitalier, Personnel sanitaire, Asthme, Etiologie, Homme, Toxicité, Médecine travail, Appareil respiratoire pathologie, Bronchopneumopathie obstructive
Mots-clés Pascal anglais : Glutaral, Antiseptic, Disinfecting agent, Occupational exposure, Hospital environment, Health staff, Asthma, Etiology, Human, Toxicity, Occupational medicine, Respiratory disease, Obstructive pulmonary disease
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0519852
Code Inist : 002B11B. Création : 18/05/2000.