Effects of occupational chronic co-exposure to n-hexane, toluen, and methyl ethyl ketone on NK cell activity and some immunoregulatory cytokine levels in shoe workers.
1 To evaluate the effects of occupational long-term co-exposure to n-hexane, toluen, and methyl ethyl ketone (MEK) on NK cell activity and serum IL-2, gamma-IFN levels, we studied a group of workers employed in a shoe factory where the jobs include use of glues and adhesives containing mainly n-hexane, and at low concentrations, toluen and MEK. 2 No differences were found in these parameters even in those workers with 3.3-fold higher mean levels of urine, 2,5-Hxdn and approximately twofold higher mean levels of urine hippuric acid as compared to controls. 3 We conclude that chronic co-exposure to n-hexane, toluen, and MEK at these levels is not associated with an impairment on either NK cell activity or serum IL-2 and gamma-IFN levels.
Mots-clés Pascal : Solvant organique, Hexane, Toluène, Butan-2-one, Cétone, Toxicité, Chronique, Association toxique, Exposition professionnelle, Médecine travail, Cellule NK, Cytokine, Homme, Immunopathologie, Industrie chaussure
Mots-clés Pascal anglais : Organic solvent, Hexane, Toluene, 2-Butanone, Ketone, Toxicity, Chronic, Toxic association, Occupational exposure, Occupational medicine, Natural killer cell, Cytokine, Human, Immunopathology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0519490
Code Inist : 002B03L04. Création : 18/05/2000.