The effect of stress on the onset and progression of Creutzfeldt-Jakob disease : Results of a German pilot case-control study.
The association between Creutzfeldt-Jakob disease (CJD) and stressful life events was examined in a pilot case-control study in Germany.
The study sample consisted of 37 CJD cases and 37 controls, both groups were frequency-matched for age and sex.
In standardised interviews of close relatives of the cases and the controls, all stressful life events were assessed and subsequently grouped into one of the following three subgroups : psychosocial stress events, medical operations with hospitalisation, and other serious medical examinations.
A significantly higher proportion of CJD cases experienced stressful life events during the last six months before disease onset than controls (65% vs. 32%, p=0.01), yielding an odds ratio (OR) of 3.85 (95% confidence interval (CI) : 1.33-11.30).
We found the clearest distinction between cases and controls for the subgroup of medical operations where an OR of 6.97 (95% CI : 0.76-329.20) was observed.
Further data indicated that stressful events seem to influence not only the onset of CJD but also the progression of the disease.
Although based on a rather small study sample, this pilot case-control investigation suggests evidence that stressful life events in the last six months before disease onset may influence CJD occurrence and may modify the course of disease. (...)
Mots-clés Pascal : Encéphalopathie spongiforme Creutzfeldt Jakob, Infection, Stress, Epidémiologie, Facteur risque, Homme, Allemagne, Europe, Prion, Etude cas témoin, Système nerveux pathologie, Système nerveux central pathologie, Encéphale pathologie, Maladie dégénérative
Mots-clés Pascal anglais : Creutzfeldt Jakob disease, Infection, Stress, Epidemiology, Risk factor, Human, Germany, Europe, Prion, Case control study, Nervous system diseases, Central nervous system disease, Cerebral disorder, Degenerative disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0517130
Code Inist : 002B17G. Création : 18/05/2000.