Is there an association between Helicobacter pylori infection and coronary heart disease ?
In addition to gastroduodenal diseases, Helicobacter pylori infection has been associated with extradigestive diseases, including coronary heart disease.
Different studies have failed to demonstrate a clear association.
The aim of this work was to carry out a meta-analysis of these studies'results, with a special emphasis on heterogeneity.
A MEDLINE search of all studies published in English from 1994 to 1998 was conducted.
Five criteria for eligibility of studies were defined.
The quality of each study was assessed on a five-point scale adapted from studies by the Quebec Task Force.
The final results are reported based on a fixed-effects model.
Pooled odd ratios were calculated for subgroups of studies (defined on quality of adjustment, on confounding factors, and on the type of control population).
Sixty-nine articles and abstracts fulfilling the defined criteria were analyzed.
They were all case-control or cross-sectional studies.
H. pylori diagnosis was carried out by serology, urea breath test or both ; coronary heart disease was diagnosed mainly by coronary angiography.
The total sample size was 6603.
The quality score varied from 4 to 10.
The pooled odds ratios of the 24 articles included in the model was 1.55 (95% confidence interval (CI) : 1.38-1.74).
It ranged from 1.07 to 2.34 when the quality of adjustment for confounding factors was considered and from 1.25 to 1.99 when the type of control group was considered. (...)
Mots-clés Pascal : Cardiopathie coronaire, Helicobacter pylori, Spirillaceae, Spirillales, Bactérie, Bactériose, Infection, Tube digestif pathologie, Epidémiologie, Facteur risque, Méthodologie, Biais méthodologique, Homme, Métaanalyse, Appareil circulatoire pathologie
Mots-clés Pascal anglais : Coronary heart disease, Helicobacter pylori, Spirillaceae, Spirillales, Bacteria, Bacteriosis, Infection, Gastrointestinal diseases, Epidemiology, Risk factor, Methodology, Methodological bias, Human, Metaanalysis, Cardiovascular disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0515286
Code Inist : 002B05B02F. Création : 18/05/2000.