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  1. Is there an association between Helicobacter pylori infection and coronary heart disease ?

    Article - En anglais

    In addition to gastroduodenal diseases, Helicobacter pylori infection has been associated with extradigestive diseases, including coronary heart disease.

    Different studies have failed to demonstrate a clear association.

    The aim of this work was to carry out a meta-analysis of these studies'results, with a special emphasis on heterogeneity.

    A MEDLINE search of all studies published in English from 1994 to 1998 was conducted.

    Five criteria for eligibility of studies were defined.

    The quality of each study was assessed on a five-point scale adapted from studies by the Quebec Task Force.

    The final results are reported based on a fixed-effects model.

    Pooled odd ratios were calculated for subgroups of studies (defined on quality of adjustment, on confounding factors, and on the type of control population).

    Sixty-nine articles and abstracts fulfilling the defined criteria were analyzed.

    They were all case-control or cross-sectional studies.

    H. pylori diagnosis was carried out by serology, urea breath test or both ; coronary heart disease was diagnosed mainly by coronary angiography.

    The total sample size was 6603.

    The quality score varied from 4 to 10.

    The pooled odds ratios of the 24 articles included in the model was 1.55 (95% confidence interval (CI) : 1.38-1.74).

    It ranged from 1.07 to 2.34 when the quality of adjustment for confounding factors was considered and from 1.25 to 1.99 when the type of control group was considered. (...)

    Mots-clés Pascal : Cardiopathie coronaire, Helicobacter pylori, Spirillaceae, Spirillales, Bactérie, Bactériose, Infection, Tube digestif pathologie, Epidémiologie, Facteur risque, Méthodologie, Biais méthodologique, Homme, Métaanalyse, Appareil circulatoire pathologie

    Mots-clés Pascal anglais : Coronary heart disease, Helicobacter pylori, Spirillaceae, Spirillales, Bacteria, Bacteriosis, Infection, Gastrointestinal diseases, Epidemiology, Risk factor, Methodology, Methodological bias, Human, Metaanalysis, Cardiovascular disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0515286

    Code Inist : 002B05B02F. Création : 18/05/2000.