Antenatal glucocorticoid treatment and cystic periventricular leukomalacia in very premature infants.
Background Antenatal glucocorticoid therapy decreases the incidence of several complications among very premature infants.
However, its effect on the occurrence of cystic periventricular leukomalacia, a major cause of cerebral palsy, remains unknown.
Methods We retrospectively analyzed a cohort of 883 live-born infants, with gestational ages ranging from 24 to 31 weeks, who were born between January 1993 and December 1996 at three perinatal centers in the Paris area.
The mothers of 361 infants had received betamethasone before delivery, the mothers of 165 infants had received dexamethasone before delivery, and the mothers of 357 infants did not receive glucocorticoids.
We compared the rates of cystic periventricular leukomalacia among the three groups of infants in bivariate and multivariate analyses after adjustment for confounding factors.
Results The rate of cystic periventricular leukomalacia was 4.4 percent among the infants whose mothers had received betamethasone, 11.0 percent among the infants whose mothers had received dexamethasone, and 8.4 percent among the infants whose mothers had not received a glucocorticoid. (...)
Mots-clés Pascal : Leucomalacie périventriculaire, Glucocorticoïde, Chimiothérapie, Traitement, Prénatal, Prévention, Complication, Prématurité, Epidémiologie, Incidence, Toxicité, Nourrisson, Homme, Système nerveux pathologie, Système nerveux central pathologie, Encéphale pathologie, Cérébrovasculaire pathologie, Ramollissement cérébral, Appareil circulatoire pathologie, Vaisseau sanguin pathologie, Foetus pathologie, Gestation pathologie
Mots-clés Pascal anglais : Periventricular leukomalacia, Glucocorticoid, Chemotherapy, Treatment, Prenatal, Prevention, Complication, Prematurity, Epidemiology, Incidence, Toxicity, Infant, Human, Nervous system diseases, Central nervous system disease, Cerebral disorder, Cerebrovascular disease, Cerebral infarction, Cardiovascular disease, Vascular disease, Fetal diseases, Pregnancy disorders
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0514781
Code Inist : 002B02U01. Création : 18/05/2000.