Objective To evaluate the predictive value of demographic and clinical features and of the results of an office-based test for Helicobacter pylori antibodies, in the presence of organic dyspepsia.
Design Over a 1-week period, 2206 consecutive patients first referred for endoscopy in 246 Italian centres were included.
Methods Demographic and clinical features, endoscopy findings, and histological diagnosis of H. pylori infection were recorded for all patients.
IgG antibodies to H. pylori were determined in 2128 cases by a rapid, immunochromatographic method (Flex Sure HP, S.K.D., San José, CA).
Results Endoscopic abnormalities were found in 939 patients (42.6%). Histologically assessed H. pylori infection was predictive for duodenal ulcer (odds ratio (OR), 6.79 ; 95% confidence interval (CI), 4.4-10.5).
Being male (OR, 1.97 ; 95% CI, 1.7-2.3), older than 40 years (OR, 1.81 ; 95% CI, 1.5-2.2), a smoker (OR, 1.88 ; 95% CI, 1.6-2.3), and presenting nocturnal awakening (OR, 1.62 ; 95% CI, 1.3-2.0) were independently associated with secondary dyspepsia.
Epigastric (OR, 1.50 ; 95% CI, 1.2-1.9) and retrosternal pain (OR, 1.39 ; 95% CI, 1.1-1.8) severe enough to affect the usual activities were predictive of organic diseases.
The results of the Flex Sure HP test correlated poorly with histological findings. (...)
Mots-clés Pascal : Dyspepsie, Etiopathogénie, Valeur prédictive, Helicobacter pylori, Spirillaceae, Spirillales, Bactérie, Anticorps, Questionnaire, Laparoscopie, Histologie, Facteur sociodémographique, Italie, Europe, Evaluation, Résultat, Homme, Appareil digestif pathologie, Bactériose, Infection, Endoscopie
Mots-clés Pascal anglais : Dyspepsia, Etiopathogenesis, Predictive value, Helicobacter pylori, Spirillaceae, Spirillales, Bacteria, Antibody, Questionnaire, Laparoscopy, Histology, Sociodemographic factor, Italy, Europe, Evaluation, Result, Human, Digestive diseases, Bacteriosis, Infection, Endoscopy
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0514691
Code Inist : 002B24E06. Création : 18/05/2000.