Long-term blood product transfusion support for patients with myelodysplastic syndromes (MDS) : cost analysis and complications.
Patients with myelodysplastic syndromes (MDS) frequently become dependent on blood transfusions.
We analyzed the total transfusion support required, and its complications and cost, following the diagnosis of MDS (total period=79.7 patient-years) in 50 patients followed at the Minneapolis VA Medical Center.
From diagnosis of MDS to transformation to AML or death (the MDS phase), 41 patients (82%) required transfusions.
The median numbers of transfused blood products per patient per year of follow-up in the MDS phase were : packed red blood cells (pRBC), 11.1 (range, 0-91.3) units, random donor platelets (RDP), 6.8 (range, 0-581) units, and single donor apheresis platelet packs (SDP) : 0 (range, 0-40) collections.
In the AML phase (time from diagnosis of secondary AML to death or last follow-up), median transfusion requirements per patient (n=5) were 24 (range, 8-88) units pRBC, 94 (range, 24-480) units RDP and 3 (range, 0-19) collections of SDP.
Overall, 80% of patients required either special processing or selection of blood products, had reactions to blood products or required premedications (specified/complicated transfusions) ; 94% of all pRBC and 97% of all platelet transfusions were specified/complicated.
The median cost of transfusions per patient was $4048 (range, $0-73 210) during the MDS phase and $13 210 (range, $5288-59 010) during the AML phase. (...)
Mots-clés Pascal : Myélodysplasique syndrome, Transfusion, Constituant sang, Long terme, Traitement, Analyse coût, Economie santé, Complication, Homme, Erythrocyte, Thrombocyte, Hémopathie maligne
Mots-clés Pascal anglais : Myelodysplastic syndrome, Transfusion, Blood product, Long term, Treatment, Cost analysis, Health economy, Complication, Human, Red blood cell, Platelet, Malignant hemopathy
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0514528
Code Inist : 002B27D01. Création : 18/05/2000.