Objectives To study the epidemiological features, clinical profile and drug utilization patterns of patients with Crohn's disease (CD).
Design A cross-sectional study of 635 Spanish patients with CD Included through a stratified and proportional random sampling.
Results The mean age of the patients was 33 years (SD 11.9) (52% were women).
Nine per cent of the patients had a family history of CD and 14% had a history of inflammatory bowel disease (IBD).
Over half (54%) of the patients were smokers.
The most frequent localization of CD was ileocolonic involvement (47%). Twelve per cent had peri-anal disease.
Regarding symptom pattern, 23% of the patients had chronic active disease and 42% had experienced no relapses during the previous 12 months.
Compared with the inflammatory pattern, fistulizing pattern was associated with a significantly higher proportion of patients with chronic active disease, a higher number of relapses per year, and a higher incidence of post-surgical relapses.
Sixty-one per cent of the patients had complications and 35% were hospitalized.
Acute relapse and bowel stricture were the most common complications.
The need for hospitalization was higher in patients with fistulizing pattern.
Regarding medication, 77% and 41% of the patients were taking aminosalicylates and corticosteroids respectively, mainly on a long-term basis.
Mean daily doses (MDD) were 2.2 g/day and 31.7 mg/day respectively. (...)
Mots-clés Pascal : Entérite Crohn, Epidémiologie, Etude transversale, Stade clinique, Complication, Traitement, Médicament, Prévalence, Répartition géographique, Hospitalisation, Homme, Résultat, Espagne, Europe, Appareil digestif pathologie, Intestin pathologie, Maladie inflammatoire, Chimiothérapie, Organisation santé
Mots-clés Pascal anglais : Crohn disease, Epidemiology, Cross sectional study, Clinical stage, Complication, Treatment, Drug, Prevalence, Geographic distribution, Hospitalization, Human, Result, Spain, Europe, Digestive diseases, Intestinal disease, Inflammatory disease, Chemotherapy, Public health organization
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0514036
Code Inist : 002B13B03. Création : 18/05/2000.