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  1. Estimation of the direct and indirect effects of vaccination.

    Article - En anglais

    Indirect effects play a major role in the protection afforded by a vaccination programme.

    In this work we define new measures of direct, indirect and total (direct+indirect) effects of a vaccination programme in terms of the protection they provide to unvaccinated and vaccinated individuals, and to the entire population.

    We show how these measures can be estimated using data from a vaccine trial or an observational study.

    The bias and standard errors of these estimates can be evaluated via stochastic simulations.

    Examples from a mumps outbreak and a (hypothetical) HIV vaccine trial are used to illustrate the estimation of these new measures of vaccination effectiveness.

    Mots-clés Pascal : Vaccination, Programme sanitaire, Essai clinique, Donnée observation, Erreur systématique, Méthode stochastique, Efficacité, Virus oreillons, Rubulavirus, Paramyxovirinae, Paramyxoviridae, Mononegavirales, Virus, Méthode statistique

    Mots-clés Pascal anglais : Vaccination, Sanitary program, Clinical trial, Observation data, Bias, Stochastic method, Efficiency, Mumps virus, Rubulavirus, Paramyxovirinae, Paramyxoviridae, Mononegavirales, Virus, Statistical method

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0508929

    Code Inist : 002B30A01C. Création : 22/03/2000.