Background Enteroviruses can cause outbreaks of hand-foot-and-mouth disease (characterized by vesicular lesions on the hands, feet, and oral mucosa) or herpangina, usually without life-threatening manifestations.
In 1998 an epidemic of enterovirus 71 infection caused hand-foot-and-mouth disease and herpangina in thousands of people in Taiwan, some of whom died.
Methods We assessed the epidemiologic aspects of this outbreak.
Cases of hand-foot-and-mouth disease or herpangina in ambulatory patients were reported to the Taiwan Department of Health by a mean of 818 sentinel physicians.
Severe cases in hospitalized patients were reported by 40 medical centers and regional hospitals.
Viruses were isolated by 10 hospital laboratories and the department of health.
Results The sentinel physicians reported 129,106 cases of hand-foot-and-mouth disease or herpangina in two waves of the epidemic, which probably represents less than 10 percent of the estimated total number of cases.
There were 405 patients with severe disease, most of whom were five years old or younger ; severe disease was seen in all regions of the island.
Complications included encephalitis, aseptic meningitis, pulmonary edema or hemorrhage, acute flaccid paralysis, and myocarditis.
Seventy-eight patients died, 71 of whom (91 percent) were five years of age or younger.
Of the patients who died, 65 (83 percent) had pulmonary edema or pulmonary hemorrhage. (...)
Mots-clés Pascal : Bouche main pied syndrome, Virose, Infection, Enterovirus, Picornaviridae, Virus, Epidémie, Enfant, Homme, Forme clinique, Taiwan, Asie, Epidémiologie, Incidence, Age apparition, Complication, Evolution, Mort, Entérovirus 71
Mots-clés Pascal anglais : Hand foot and mouth disease, Viral disease, Infection, Enterovirus, Picornaviridae, Virus, Epidemic, Child, Human, Clinical form, Taiwan, Asia, Epidemiology, Incidence, Age of onset, Complication, Evolution, Death
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0508808
Code Inist : 002B05C02B. Création : 22/03/2000.