Neurologic complications in children with enterovirus 71 infection.
Background Enterovirus 71 infection causes hand foot-and-mouth disease in young children, which is characterized by several days of fever and vomiting ulcerative lesions in the oral mucosa, and vesicles on the backs of the hands and feet.
The initial illness resolves but is sometimes followed by aseptic men ingitis, encephalomyelitis, or even acute flaccid pa ralysis similar to paralytic poliomyelitis.
Methods We describe the neurologic complications associated with the enterovirus 71 epidemic that oc curred in Taiwan in 1998.
At three major hospitals we identified 41 children with culture-confirmed entero virus 71 infection and acute neurologic manifesta tions.
Magnetic resonance imaging (MRI) was per formed in 4 patients with acute flaccid paralysis and 24 with rhombencephalitis.
Results The mean age of the patients was 2.5 years (range, 3 months to 8.2 years).
Twenty-eight patients had hand-foot-and-mouth disease (68 per cent), and six had herpangina (15 percent).
The other seven patients had no skin or mucosal lesions.
Three neurologic syndromes were identified :
aseptic menin gitis (in 3 patients) ;
brain-stem encephalitis, or rhomb encephalitis (in 37) ;
and acute flaccid paralysis (in 4) which followed rhombencephalitis in 3 patients.
Ir 20 patients with rhombencephalitis, the syndrome was characterized by myoclonic jerks and tremor ataxia, or both (grade I disease).
Ten patients had myoclonus and cranial-nerve involvement (grade I disease). (...)
Mots-clés Pascal : Bouche main pied syndrome, Virose, Infection, Enterovirus, Picornaviridae, Virus, Enfant, Homme, Complication, Taiwan, Asie, Epidémiologie, Incidence, Classification, Imagerie RMN, Exploration radiologique, Epidémie, Système nerveux pathologie, Système nerveux central pathologie, Imagerie médicale, Entérovirus 71
Mots-clés Pascal anglais : Hand foot and mouth disease, Viral disease, Infection, Enterovirus, Picornaviridae, Virus, Child, Human, Complication, Taiwan, Asia, Epidemiology, Incidence, Classification, Nuclear magnetic resonance imaging, Radiologic investigation, Epidemic, Nervous system diseases, Central nervous system disease, Medical imagery
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0508782
Code Inist : 002B05C02B. Création : 22/03/2000.