During 1997, a total of 4,267 nosocomial and community-acquired bloodstream infections due to gram-negative organisms were reported from SENTRY hospitals in Canada (8 sites), the United States (30 sites), and Latin America (10 sites).
Escherichia coli was the most common isolate (41% of all gram-negative isolates), followed by Klebsiella species (17.9%), Pseudomonas aeruginosa (10.6%), and Enterobacter species (9.4%). For all gram-negative isolates combined, the most active antimicrobials tested were meropenem, imipenem, and cefepime.
The quinolones levofloxacin (MIC90,2 mug/mL), ciprofloxacin (MIC90,1 mug/mL), gatifloxacin (MIC90,2 mug/mL), sparfloxacin (MIC90,2 mug/mL), and trovafloxacin (MIC90,2 mug/mL) were also active against most isolates.
Bloodstream infection isolates from Latin America were uniformly more resistant to all classes of antimicrobial agents tested than were isolates from Canada or the United States.
Resistance phenotypes consistent with extended-spectrum bêta-lactamase production were also most common among E. coli and Klebsiella species from Latin America.
Further investigation of the reasons for regional differences in resistance patterns is needed, as is ongoing surveillance to detect resistance trends and to guide antimicrobial use.
Mots-clés Pascal : Bactériémie, Bactériose, Infection, Antibactérien, Antibiotique, Programme sanitaire, Infection nosocomiale, Infection communautaire, Bactérie Gram négatif, Fréquence, Etats Unis, Amérique du Nord, Amérique, Canada, Etude statistique, Amérique Latine, Antimicrobien, Test sensibilité médicamenteuse, Surveillance sanitaire
Mots-clés Pascal anglais : Bacteremia, Bacteriosis, Infection, Antibacterial agent, Antibiotic, Sanitary program, Nosocomial infection, Community acquired infection, Gram negative bacteria, Frequency, United States, North America, America, Canada, Statistical study, Latin America, Antimicrobial agent, Drug susceptibility test, Sanitary surveillance
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0507679
Code Inist : 002B05B02M. Création : 22/03/2000.