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  1. Exposure assessment of high molecular weight sensitisers : contribution to occupational epidemiology and disease prevention.

    Article - En anglais

    An important group of sensitising agents are so called high molecular weight sensitisers-proteins or glycoproteins with molecular weights in the 5-70 kDa range that can provoke a specific IgE response in workers exposed to these agents.

    Exposure to high molecular weight sensitisers could only be evaluated indirectly in the recent past.

    Few measurement techniques existed that made it possible to measure the allergens directly.

    As a result, few studies focused on establishing exposure-response relations, and exposure standards have not been established for high molecular weight sensitisers, or those that have are of doubtful scientific basis.

    Recent use of immunoassays changed this perspective dramatically.

    Antibodies used in the assays can originate from human serum (sensitised workers), serum from sensitised animals (rabbits producing polyclonal antibodies), or animal derived cell cultures producing monoclonal antibodies.

    Although few comparative studies exist, the available evidence suggests that although the correlation of allergen concentrations obtained with different assays is good, large systematic differences occur.

    The use of conversion factors to make data from previously performed allergen measurements comparable or exchangeable is limited and thorough standardisation of assays is preferred.

    Validation and comparison of different assays by comparisons between laboratories seem important issues that have not received the attention needed. (...)

    Mots-clés Pascal : Composé chimique, Sensibilisation, Masse moléculaire, Haut, Protéine, Toxicité, Allergie, Détection, Homme, Exposition professionnelle, Médecine travail, Prévention, Essai, Méthode immunologique, Immunopathologie

    Mots-clés Pascal anglais : Chemical compound, Sensitization, Molecular weight, High, Protein, Toxicity, Allergy, Detection, Human, Occupational exposure, Occupational medicine, Prevention, Test, Immunological method, Immunopathology

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0507011

    Code Inist : 002B06C02. Création : 22/03/2000.