Drug resistance patterns, genetic subtypes, clinical features, and risk factors in military personnel with HIV-1 seroconversion.
Regular testing of military personnel identifies early HIV infection ; this identification provides a sentinel cohort in which to describe the evolving molecular epidemiology of HIV-1 transmission.
To describe the prevalence and epidemiologic correlates associated with the acquisition of non-subtype B and drug-resistant HIV infections.
Military referral hospital.
95 military personnel with HIV-1 seroconversion.
Self-reported questionnaire, CD4 cell counts, plasma HIV-1 RNA levels, and nucleic acid sequence analysis for drug-resistant mutations and HIV-1 genetic subtype.
95 patients were enrolled between February 1997 and February 1998.
The likely geographic location of HIV-1 acquisition was overseas in 8% of patients, the United States in 68%, and either overseas or the United States in 24%. Seven patients (7.4%) had subtype E infection ; the remainder had subtype B infection.
Eight of 31 (26%) treatment-naive patients had mutations in the reverse transcriptase or protease gene associated with drug resistance.
The percentage of HIV-1 non-subtype B infection and antiretroviral drug-resistant mutations was relatively high in U.S. military personnel with recently acquired HIV-1 infection.
Mots-clés Pascal : SIDA, Virose, Infection, Virus HIV1, Virus immunodéficience humaine, Lentivirus, Retroviridae, Virus, Epidémiologie, Résistance traitement, Prévalence, Soustype, Génétique, Etude transversale, Facteur risque, Militaire, Personnel, Homme, Transmission, Immunopathologie, Immunodéficit, Séroconversion
Mots-clés Pascal anglais : AIDS, Viral disease, Infection, HIV-1 virus, Human immunodeficiency virus, Lentivirus, Retroviridae, Virus, Epidemiology, Negative therapeutic reaction, Prevalence, Subtype, Genetics, Cross sectional study, Risk factor, Military, Personnel, Human, Transmission, Immunopathology, Immune deficiency
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0505674
Code Inist : 002B05C02D. Création : 22/03/2000.