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  1. Drug resistance patterns, genetic subtypes, clinical features, and risk factors in military personnel with HIV-1 seroconversion.

    Article - En anglais

    Background 

    Regular testing of military personnel identifies early HIV infection ; this identification provides a sentinel cohort in which to describe the evolving molecular epidemiology of HIV-1 transmission.

    Objective 

    To describe the prevalence and epidemiologic correlates associated with the acquisition of non-subtype B and drug-resistant HIV infections.

    Design 

    Cross-sectional study.

    Setting 

    Military referral hospital.

    Patients 

    95 military personnel with HIV-1 seroconversion.

    Measurements 

    Self-reported questionnaire, CD4 cell counts, plasma HIV-1 RNA levels, and nucleic acid sequence analysis for drug-resistant mutations and HIV-1 genetic subtype.

    Results 

    95 patients were enrolled between February 1997 and February 1998.

    The likely geographic location of HIV-1 acquisition was overseas in 8% of patients, the United States in 68%, and either overseas or the United States in 24%. Seven patients (7.4%) had subtype E infection ; the remainder had subtype B infection.

    Eight of 31 (26%) treatment-naive patients had mutations in the reverse transcriptase or protease gene associated with drug resistance.

    Conclusions 

    The percentage of HIV-1 non-subtype B infection and antiretroviral drug-resistant mutations was relatively high in U.S. military personnel with recently acquired HIV-1 infection.

    Mots-clés Pascal : SIDA, Virose, Infection, Virus HIV1, Virus immunodéficience humaine, Lentivirus, Retroviridae, Virus, Epidémiologie, Résistance traitement, Prévalence, Soustype, Génétique, Etude transversale, Facteur risque, Militaire, Personnel, Homme, Transmission, Immunopathologie, Immunodéficit, Séroconversion

    Mots-clés Pascal anglais : AIDS, Viral disease, Infection, HIV-1 virus, Human immunodeficiency virus, Lentivirus, Retroviridae, Virus, Epidemiology, Negative therapeutic reaction, Prevalence, Subtype, Genetics, Cross sectional study, Risk factor, Military, Personnel, Human, Transmission, Immunopathology, Immune deficiency

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0505674

    Code Inist : 002B05C02D. Création : 22/03/2000.