The results of previous epidemiologic research on the possible association between maternal smoking during pregnancy and risk of oral clefts in offspring have been inconsistent.
This may be due in part to methodological limitations, including imprecise measurement of tobacco use, failure to consider etiologic heterogeneity among types of oral clefts, and confounding.
This analysis, based on a large case-control study, further evaluated the effect of first trimester maternal smoking on oral facial cleft risk by examining the dose-response relationship according to specific cleft type and according to whether or not additional malformations were present.
A number of factors, including dietary and supplemental folate intake and family history of clefts, were evaluated as potential confounders and effect modifiers.
Data on 3,774 mothers interviewed between 1976 and 1992 by the Slone Epidemiology Unit Birth Defects Study were used.
Study subjects were actively ascertained from sites in areas around Boston, Massachusetts and Philadelphia, Pennsylvania ; the state of Iowa ; and southeastern Ontario, Canada.
Cases were infants with isolated defects-cleft lip alone (n=334), cleft lip and palate (n=494), or cleft palate alone (n=244) - and infants with clefts plus (+) additional malformations : cleft Ilp+ (n=58), cleft lip and palate+ (n=140), or cleft palate+ (n=209). (...)
Mots-clés Pascal : Tabagisme, Mère, Gestation, Bec de lièvre, Malformation, Maladie congénitale, Anomalie, Cavité buccale, Voile palais, Nouveau né pathologie, Epidémiologie, Facteur risque, Nouveau né, Homme, Etude cas témoin, Etats Unis, Amérique du Nord, Amérique, Exposition, Gestation pathologie, Foetus pathologie, ORL pathologie, Cavité buccale pathologie, Tabagisme passif
Mots-clés Pascal anglais : Tobacco smoking, Mother, Pregnancy, Cleft lip, Malformation, Congenital disease, Anomaly, Oral cavity, Palatine velum, Newborn diseases, Epidemiology, Risk factor, Newborn, Human, Case control study, United States, North America, America, Exposure, Pregnancy disorders, Fetal diseases, ENT disease, Oral cavity disease, Passive smoking
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0505551
Code Inist : 002B20F02. Création : 22/03/2000.