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  1. Factors associated with axillary lymph node metastasis from breast carcinoma : Descriptive and predictive analyses.

    Article - En anglais


    Although axillary lymph node metastasis is one of the most important prognostic determinants of breast carcinoma prognoses, the reasons why tumors vary in their capability to produce for axillary metastases remain unclear.


    The authors used data from the nationwide Patient Care Evaluation (PCE) survey of the American College of Surgeons to evaluate the correlations between patient/tumor characteristics and lymph node status, and to explore the use of these factors, which are all known prior to axillary dissection, in predicting lymph node status.

    The PCE data set contained 18,025 breast carcinoma cases diagnosed in 1990 after exclusion of women older than 79 years or with fewer than 6 lymph nodes examined.


    In a multivariate logistic regression model, larger tumor size, young age, African American or Hispanic race, outer half tumor location, poor or moderate differentiation, aneuploidy, and infiltrating ductal histology were independently associated with a higher likelihood of one or more positive lymph nodes.

    Contrary to expectation, cases negative for estrogen receptor (ER) and progesterone receptor (PR) had a lower risk of positive lymph nodes when adjusted for other factors (odds ratio=0.82 ; 95% confidence interval : 0.74-0.91) compared with cases positive for both receptors. (...)

    Mots-clés Pascal : Carcinome, Glande mammaire, Métastase, Ganglion axillaire, Adénopathie maligne, Modèle mathématique, Taille, Grade histologique, Histopathologie, Age, Race, Ethnie, Oestrogène, DNA, Diploïdie, Progestérone, Récepteur hormonal, Récepteur biologique, Facteur risque, Epidémiologie, Etats Unis, Amérique du Nord, Amérique, Homme, Tumeur maligne, Glande mammaire pathologie, Anatomopathologie, Génétique, Hormone stéroïde sexuelle, Hormone ovarienne, Hémopathie maligne

    Mots-clés Pascal anglais : Carcinoma, Mammary gland, Metastasis, Axillary ganglion, Malignant lymphadenopathy, Mathematical model, Size, Histological grading, Histopathology, Age, Race, Ethnic group, Estrogen, DNA, Diploidy, Progesterone, Hormonal receptor, Biological receptor, Risk factor, Epidemiology, United States, North America, America, Human, Malignant tumor, Mammary gland diseases, Pathology, Genetics, Sex steroid hormone, Ovarian hormone, Malignant hemopathy

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0505139

    Code Inist : 002B20E02. Création : 22/03/2000.