Background Body-mass index (the weight in kilograms divided by the square of the height in meters) is known to be associated with overall mortality.
We investigated the effects of age, race, sex, smoking status, and history of disease on the relation between body-mass index and mortality.
Methods In a prospective study of more than 1 million adults in the United States (457,785 men and 588,369 women), 201,622 deaths occurred during 14 years of follow-up.
We examined the relation between body-mass index and the risk of death from all causes in four subgroups categorized according to smoking status and history of disease.
In healthy people who had never smoked, we further examined whether the relation varied according to race, cause of death, or age.
The relative risk was used to assess the relation between mortality and body-mass index.
Results The association between body-mass index and the risk of death was substantially modified by smoking status and the presence of disease.
In healthy people who had never smoked, the nadir of the curve for body-mass index and mortality was found at a body-mass index of 23.5 to 24.9 in men and 22.0 to 23.4 in women.
Among subjects with the highest body-mass indexes, white men and women had a relative risk of death of 2.58 and 2.00, respectively, as compared with those with a body-mass index of 23.5 to 24.9. Black men and women with the highest body-mass indexes had much lower risks of death (1.35 and 1. (...)
Mots-clés Pascal : Indice masse corporelle, Etude cohorte, Association, Mortalité, Facteur risque, Etiopathogénie, Race, Sexe, Critère âge, Etats Unis, Amérique du Nord, Amérique, Evaluation, Homme, Métabolisme pathologie, Organisation santé, Prévention, Ethnie
Mots-clés Pascal anglais : Body mass index, Cohort study, Association, Mortality, Risk factor, Etiopathogenesis, Race, Sex, Age criterion, United States, North America, America, Evaluation, Human, Metabolic diseases, Public health organization, Prevention, Ethnic group
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0505008
Code Inist : 002B24O14. Création : 22/03/2000.