logo BDSP

Base documentaire


Votre avis nous intéresse

Le réseau BDSP met en oeuvre un projet d'innovation et d'amélioration de ses services, dans le souci constant de proposer des contenus de qualité adaptés aux besoins des utilisateurs.

Identifier de nouvelles sources de financements est la condition nécessaire pour assurer la poursuite et la pérennité de cet outil unique qu'est la BDSP, tout en le faisant évoluer.

Pour définir un nouveau modèle économique, nous avons besoin de votre avis : merci de répondre à notre enquête (temps estimé : 5 minutes).

Participer maintenant
Participer plus tard J'ai déjà participé

  1. Association between coffee drinking and K-ras mutations in exocrine pancreatic cancer.

    Article - En anglais

    Study objective-To analyse the relation between coffee consumption and mutations in the K-ras gene in exocrine pancreatic cancer.

    Design-Case-case study.

    Consumption of coffee among cases with the activating mutation in the K-ras gene was compared with that of cases without the mutation.

    Setting and patients-All cases of pancreatic cancer newly diagnosed at five hospitals in Spain during three years were included in the PANKRAS II Study (n=185, of whom 121 whose tissue was available for molecular analysis are the object of the present report).

    Over 88% were personally interviewed in hospital.

    DNA was amplified from paraffin wax embedded tissues, and mutations in codon 12 of K-ras were detected by the artificial RFLP technique.

    Main results-Mutations were found in tumours from 94 of 121 patients (77.7%). Mutations were more common among regular coffee drinkers than among non-regular coffee drinkers (82.0% v 55.6%, p=0.018, n=107).

    The odds ratio adjusted by age, sex, smoking and alcohol drinking was 5.41 (95% CI 1.64,17.78).

    The weekly intake of coffee was significantly higher among patients with a mutated tumour (mean of 14.5 cups/week v 8.8 among patients with a wild type tumour, p<0.05).

    With respect to non-regular coffee drinkers, the odds ratio of a mutated tumour adjusted by age, sex, smoking and alcohol drinking was 3.26 for drinkers of 2-7 cups/week, 5.77 for drinkers of 8-14 cups/week and 9.99 for drinkers of >=15 cups/week (p<0.01, test for trend). (...)

    Mots-clés Pascal : Café, Consommation, Mutation, Gène, Tumeur maligne, Pancréas exocrine, Génétique, Epidémiologie, Facteur risque, Homme, Espagne, Europe, Alimentation, Appareil digestif pathologie, Pancréas pathologie, Gène K-ras

    Mots-clés Pascal anglais : Coffee, Consumption, Mutation, Gene, Malignant tumor, Exocrine pancreas, Genetics, Epidemiology, Risk factor, Human, Spain, Europe, Feeding, Digestive diseases, Pancreatic disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0503454

    Code Inist : 002B13C01. Création : 22/03/2000.