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  1. Minor and major Depression and the risk of death in older persons.

    Article - En anglais


    The association between depression and mortality in older community-dwelling populations is still unresolved.

    This study determined the effect of both minor and major depression on mortality and examined the role of confounding and explanatory variables on this relationship.


    A cohort of 3056 men and women from the Netherlands aged 55 to 85 years were followed up for 4 years.

    Major depression was defined according to DSM-III criteria by means of the Diagnostic Interview Schedule.

    Minor depression was defined as clinically relevant depression (defined by a Center for Epidemiologic Studies Depression score >= 16) not fulfilling diagnostic criteria for major depression.


    After adjustment for confounding variables (sociodemographics, health status), men with minor depression had a 1.80-fold higher risk of death (95% confidence interval, 1.35-2.39) during follow-up than nondepressed men.

    In women, minor depression did not significantly increase the mortality risk.

    Irrespective of sex, major depression was associated with a 1.83-fold higher mortality risk (95% confidence interval, 1.09-3.10) after adjustment for sociodemographics and health status.

    Health behaviors such as smoking and physical inactivity explained only a small part of the excess mortality risk associated with depression. (...)

    Mots-clés Pascal : Etat dépressif, Forme clinique, Facteur risque, Mortalité, Etude cohorte, Personne âgée, Homme, Etude longitudinale, Epidémiologie, Santé mentale, Trouble humeur

    Mots-clés Pascal anglais : Depression, Clinical form, Risk factor, Mortality, Cohort study, Elderly, Human, Follow up study, Epidemiology, Mental health, Mood disorder

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0502166

    Code Inist : 002B18E. Création : 22/03/2000.