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  1. Minor and major Depression and the risk of death in older persons.

    Article - En anglais

    Background 

    The association between depression and mortality in older community-dwelling populations is still unresolved.

    This study determined the effect of both minor and major depression on mortality and examined the role of confounding and explanatory variables on this relationship.

    Methods 

    A cohort of 3056 men and women from the Netherlands aged 55 to 85 years were followed up for 4 years.

    Major depression was defined according to DSM-III criteria by means of the Diagnostic Interview Schedule.

    Minor depression was defined as clinically relevant depression (defined by a Center for Epidemiologic Studies Depression score >= 16) not fulfilling diagnostic criteria for major depression.

    Results 

    After adjustment for confounding variables (sociodemographics, health status), men with minor depression had a 1.80-fold higher risk of death (95% confidence interval, 1.35-2.39) during follow-up than nondepressed men.

    In women, minor depression did not significantly increase the mortality risk.

    Irrespective of sex, major depression was associated with a 1.83-fold higher mortality risk (95% confidence interval, 1.09-3.10) after adjustment for sociodemographics and health status.

    Health behaviors such as smoking and physical inactivity explained only a small part of the excess mortality risk associated with depression. (...)

    Mots-clés Pascal : Etat dépressif, Forme clinique, Facteur risque, Mortalité, Etude cohorte, Personne âgée, Homme, Etude longitudinale, Epidémiologie, Santé mentale, Trouble humeur

    Mots-clés Pascal anglais : Depression, Clinical form, Risk factor, Mortality, Cohort study, Elderly, Human, Follow up study, Epidemiology, Mental health, Mood disorder

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0502166

    Code Inist : 002B18E. Création : 22/03/2000.