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  1. Clinical manifestations of gallstone disease : Evidence from the Multicenter Italian Study on Cholelithiasis (MICOL).

    Article - En anglais

    Despite the many efforts to delineate the clinical manifestations of gallbladder disease, the precise symptom complex associated with gallstones is still a matter of debate, and even the existence of gallstone-specific symptoms has been questioned.

    We carried out a large population-based cross-sectional study (MICOL) to identify symptoms significantly related to gallstones.

    Fourteen centers throughout Italy enrolled 29,504 subjects aged 30 to 69 years.

    All subjects were administered an ultrasonographic examination of the upper abdomen and a precoded questionnaire.

    All subjects were divided into 4 groups :

    25,374 (86.0%) gallstone-free subjects (GF), 1,832 (6.2%) patients with gallstones not previously diagnosed (GNPD), 638 (2.2%) patients with gallstones previously diagnosed (GPD), 1,660 (5.6%) patients with a history of cholecystectomy for gallstones (CC).

    In logistic regression analysis, pain at epigastrium and, even more, pain at right hypocondrium were significantly associated with gallstones.

    For pain at right hypocondrium, this association progressively increased from GNPD (OR=1.60,95% CI=0.97-2.65) to GPD (OR=8.77,95% CI=5.27-14.61) to CC (OR=59.40,95% Cl=43.87-80.42).

    Absence of heartburn combined with right hypocondrium or epigastrium pain and intolerance to fried or fatty food were also significantly related to gallstones.

    We also found some pain characteristics significantly associated with gallstones, i.e. (...)

    Mots-clés Pascal : Lithiase, Cholédoque, Prévalence, Marqueur biologique, Incidence, Facteur risque, Symptomatologie, Etude multicentrique, Etude transversale, Résultat, Homme, Italie, Europe, Appareil digestif pathologie, Voie biliaire pathologie, Marqueur

    Mots-clés Pascal anglais : Lithiasis, Choledoch, Prevalence, Biological marker, Incidence, Risk factor, Symptomatology, Multicenter study, Cross sectional study, Result, Human, Italy, Europe, Digestive diseases, Biliary tract disease, Marker

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0496221

    Code Inist : 002B13C03. Création : 22/03/2000.