Non-insulin-dependent diabetes mellitus (NIDDM) may be associated with chronic hepatitis C virus (HCV) infection.
This was studied further in two parts.
First, 1,151 patients with HCV-related cirrhosis and 181 patients with hepatitis B virus (HBV) - related cirrhosis, well matched for age, sex, and severity of cirrhosis, were reviewed retrospectively.
The prevalence of diabetes mellitus was higher in HCV-related cirrhosis (23.6%) than in HBV-related cirrhosis (9.4% ; odds ratio [OR], 2.78 ; 95% confidence interval [CI], 1.6-4.79 ; P=0002).
The prevalence of diabetes mellitus was associated closely with the Child-Pugh score (OR, 3.83 ; 95% CI, 2.38-6.17 ; P<. 0001) and increasing age (OR, 1.02 ; 95% Cl, 1.00-1.03 ; P=0117).
Second, 235 patients with biopsy confirmed chronic HBV or HCV underwent an oral glucose tolerance test.
Only 1 of 70 patients with chronic viral hepatitis without cirrhosis was diabetic.
However, 31 of 127 patients with HCV-related cirrhosis (24.4%) were diabetic compared with 3 of 38 patients with HBV-related cirrhosis (7.9%, P=0477).
The major variables associated with NIDDM were cirrhosis (OR, 14.39 ; 95% CI, 1.91-108 ; P=0096) and male sex (OR, 4.64 ; 95% Cl, 1.32-16.18 ; P=0161).
Fasting insulin levels in 30 patients with HCV-related cirrhosis and diabetes mellitus were elevated significantly, which was consistent with insulin resistance. (...)
Mots-clés Pascal : Hépatite virale C, Virose, Infection, Chronique, Prévalence, Diabète non insulinodépendant, Association, Etude comparative, Etiopathogénie, Facteur risque, Article synthèse, Hyperglycémie provoquée, Chimiothérapie, Homme, Appareil digestif pathologie, Foie pathologie, Endocrinopathie, Biologie moléculaire
Mots-clés Pascal anglais : Viral hepatitis C, Viral disease, Infection, Chronic, Prevalence, Non insulin dependent diabetes, Association, Comparative study, Etiopathogenesis, Risk factor, Review, Glucose tolerance test, Chemotherapy, Human, Digestive diseases, Hepatic disease, Endocrinopathy, Molecular biology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0495975
Code Inist : 002B05C02G. Création : 22/03/2000.