Controversy exists regarding the potential influence of anemia and blood transfusions on the rate of retinopathy of prematurity (ROP) in premature infants.
A prospective, randomized, masked trial was performed to determine the influence of red blood cell transfusion protocol on ROP incidence and severity in a population of high-risk infants.
A total of 50 infants with birth weights<1251 g were divided randomly into two groups beginning on day of life 29.
Group 1 (n=24) received red cell transfusions during the 6-week study period, only if certain symptom-based guidelines were met.
Group 2 (n=26) received red cell transfusions to maintain the hematocrit level above 40% for the entire 6 weeks.
Infants were monitored for ROP, growth, and associated morbidity.
Serial measurements of serum glucose, lactate, ferritin, total iron-binding capacity, and iron were performed.
ROP occurred in 83% of infants in group 1, and 73% of infants in group 2. There were no statistically significant differences in ROP severity, intraventricular hemorrhage, bronchopulmonary dysplasia, necrotizing enterocolitis, or any of the laboratory values except hemoglobin (10.8 vs 13.2 g/dL) and hematocrit (33.9% vs 41.8%) between the groups.
Combining data from both groups, there was no association between hemoglobin or hematocrit ratios and ROP incidence or severity. (...)
Mots-clés Pascal : Rétinopathie, Prématuré, Anémie, Transfusion, Sang, Epidémiologie, Facteur risque, Pathogénie, Nourrisson, Homme, Prospective, Randomisation, Oeil pathologie, Hémopathie
Mots-clés Pascal anglais : Retinopathy, Premature, Anemia, Transfusion, Blood, Epidemiology, Risk factor, Pathogenesis, Infant, Human, Prospective, Randomization, Eye disease, Hemopathy
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0494661
Code Inist : 002B09I. Création : 22/03/2000.