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  1. Geographic diversity of adult T-cell leukemia/lymphoma in Brazil.

    Article - En anglais

    We describe 195 cases of adult T-cell leukemiallymphoma (ATLL) reported to the national registry of T-cell malignancies in Brazil between 1994 and 1998.

    We compared the effect of demographic differences and clinical features of 150 consecutive ATLL cases in different regions of this diverse country.

    At diagnosis, the predominant clinical sub-type was the acute type (60%), followed by lymphoma (22%), chronic (10%) and smoldering (8%) types.

    Although we expected that different sub-types would be present in different regions, on the basis of immunogenetic factors determined by ethnicity, we did not demonstrate these differences.

    There were no significant differences among ATLL subtypes by age or gender.

    No ethnic group predominated in the total population of patients, but significant differences were noted when examining ethnic distribution by region.

    Reflecting the general population distribution, white patients were seen more often in Sao Paulo and black patients in Bahia, than in other regions.

    In most regions, cases were equally distributed between blacks and mulattos, except in Pernambuco, where blacks were less frequent.

    The main clinical features were lymphadenopathy, skin lesions, hypercalcemia and hepatomegaly.

    Fourteen patients (9%) suffered from HTLV-I-associated myelopathy (HAM/TSP), either at diagnosis or during follow-up of ATLL.

    All cases but one had antibodies to HTLV-I, with concordant results with ELISA, WB and PCR analyses. (...)

    Mots-clés Pascal : Lymphome, Leucémie cellule T adulte, Virose, Infection, Forme clinique, Variation géographique, Prévalence, Epidémiologie, Pronostic, Brésil, Amérique du Sud, Amérique, Adulte, Homme, Virus HTLV1, Retroviridae, Virus, Hémopathie maligne, Lymphome non hodgkinien, Lymphoprolifératif syndrome

    Mots-clés Pascal anglais : Lymphoma, Adult T cell leukemia, Viral disease, Infection, Clinical form, Geographical variation, Prevalence, Epidemiology, Prognosis, Brazil, South America, America, Adult, Human, HTLV-I virus, Retroviridae, Virus, Malignant hemopathy, Non Hodgkin lymphoma, Lymphoproliferative syndrome

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0494569

    Code Inist : 002B19B. Création : 22/03/2000.