Cancer risk in patients with earlier diagnosis of cutaneous melanoma in situ.
We calculated the short-term and long-term risks of developing cancer among 3,766 patients with a diagnosis of cutaneous melanoma in situ in Sweden from 1958 to 1992.
In total, 393 patients developed a primary cancer at any site compared with an expected number of 177 [standardized incidence ratio (SIR)=2.2,95% confidence interval (Cl)=2.0-2.4]. Patients below 60 years of age at diagnosis had the highest SIR (2.7,95% Cl=2.3-3.2).
The overall risks were similar between men and women.
The highest risk was seen during the first year of follow-up, though the risk remained elevated also after 15 or more years of follow-up.
For specific sites, the highest SIR was found for developing invasive cutaneous malignant melanoma (SIR=22.2).
The risk of subsequent primary non-melanoma skin cancer was elevated 8-fold in men and almost 7-fold in women.
An elevated risk was also found for female breast cancer (SIR=1.4).
Especially among women, other sites with increased cancer risk (though not significant) were non-Hodgkin's lymphoma (SIR=1.9), multiple myeloma (3.2) and cancers of the colon (1.6) and pancreas (1.6).
In conclusion, patients with melanoma In situ run a generally increased risk of developing primary cancers, especially cutaneous malignant melanoma and non-melanoma skin cancer.
The increased long-term risk of cancer after diagnosis of melanoma in situ may be due to continuing carcinogenic exposure or to intrinsic tumor susceptibility.
Mots-clés Pascal : Mélanome, Peau, Facteur risque, Tumeur maligne, Hémopathie maligne, Second cancer, Cancer in situ, Epidémiologie, Suède, Europe, Homme, Peau pathologie
Mots-clés Pascal anglais : Melanoma, Skin, Risk factor, Malignant tumor, Malignant hemopathy, Second cancer, Carcinoma in situ, Epidemiology, Sweden, Europe, Human, Skin disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0494185
Code Inist : 002B04B. Création : 22/03/2000.