Hepatitis C virus (HCV) related disease follows a long, benign course and most affected patients have mild disease.
Liver biopsy is mandatory to grade and stage the disease.
Characteristic, though non-specific, HCV histological lesions such as bile duct damage and steatosis have been singled out but their association with non-histological parameters has not been completely defined.
Our aim was to study the relationships among these histological lesions and clinical, biochemical, functional and virological characteristics in a group of Northern Italian patients with chronic hepatitis.
We studied 172 patients with HCV-related chronic hepatitis.
Patients were divided into groups on the basis of histology including bile duct damage and steatosis.
Clinical, biochemical, functional and virological profiles were related to histological findings.
Histological grading and staging of disease increased as the age of patients increased.
Steatosis was present in 70% of our patients and was related to a higher degree of fibrosis and to decreased functional activity.
The prevalence of bile duct damage was 20%. This lesion was present in older patients with higher staging and impaired liver function.
Biochemically it was associated with an increase in aspartate aminotransferase, gammaglutamyltranspeptidase, alkaline phosphatase, and total bilirubin.
In the population we studied.
HCV chronic hepatitis was predominantly a mild disease. (...)
Mots-clés Pascal : Hépatite virale C, Virose, Infection, Chronique, Complication, Stéatose, Foie, Lésion, Voie biliaire, Epidémiologie, Homme, Italie, Europe, Triglycéride, Appareil digestif pathologie, Foie pathologie, Voie biliaire pathologie
Mots-clés Pascal anglais : Viral hepatitis C, Viral disease, Infection, Chronic, Complication, Steatosis, Liver, Lesion, Biliary tract, Epidemiology, Human, Italy, Europe, Triglyceride, Digestive diseases, Hepatic disease, Biliary tract disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0491586
Code Inist : 002B30A01A2. Création : 22/03/2000.