Hepatitis C infection in an Italian population not selected for risk factors.
This study estimated the prevalence of HCV infection and relationship with viremia in a general population.
The inhabitants of Albavilla town were personally invited to participate.
Out of 3997 inhabitants falling within the age range 18-85 years, 2403 (participation rate 60.1%) were examined for transaminases.
HCVAb, HCVRNA, genotype and immunoblot assay, The following information was collected : sex, age, blood transfusions, surgery, use of glass syringes, drug addiction, alcohol consumption, tattoos and body mass index.
115 (4.8%) were HCVAb+the prevalence being 1.2% under 40 years.
Transfusion in the past was the only risk factor for HCV infection.
Among the HCVAb+subjects, 71 (61.7%) were HCVRNA+40.8% of the HCVAb+/HCVRNA+group had normal ALT, compared with 68% of those with HCVAb+/HCVRNA-The HCV genotypes in the 71 HCVRNA+subjects were :
2a/2c in 58 (81.7%), 40% of them with normal ALT ;
1b in 11 (15.5%), none with normal ALT ;
genotype 3 in two (2.8%). Conclusion : The prevalence of HCVAb in this general population was 4.8%. About 3% were HCVRNA positive and of these genotype 2a/2c was present in 81.6%.
Mots-clés Pascal : Hépatite virale C, Virose, Infection, Prévalence, Séropositivité, Génotype, Epidémiologie, Homme, Italie, Europe, Appareil digestif pathologie, Foie pathologie, Génétique
Mots-clés Pascal anglais : Viral hepatitis C, Viral disease, Infection, Prevalence, Seropositivity, Genotype, Epidemiology, Human, Italy, Europe, Digestive diseases, Hepatic disease, Genetics
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0491585
Code Inist : 002B30A01A2. Création : 22/03/2000.