The causes of renal cell cancer remain incompletely understood.
In one previous retrospective case-control study, high occupational physical activity has been associated with a decreased risk among men, but not among women.
Our aim was to investigate the association between occupational physical activity and renal cell cancer in a large cohort in Sweden.
A cohort of Swedish men and women was identified in the nationwide censuses in 1960 and 1970, and the reported occupations were classified into 4 levels of physical demands.
Follow-up from 1971 through 1989 was accomplished through record linkages to the Swedish Cancer Registry.
Multivariate Poisson regression models were used to estimate relative risk (RR) and 95% confidence intervals (CI).
We found a monotonic increase in risk of renal cell cancer with decreasing level of occupational physical activity among men (p for trend<0.001).
After adjustment for socio-economic status, place of residence, and calendar year of follow-up, men with long-term sedentary jobs had a 25% (RR=1.25,95% CI 1.02-1.53) increased risk compared to men with physically demanding occupations.
Among women there was no association, the dose-risk trend was not significant (p for trend>0.50).
Occupational physical activity was inversely associated with renal cell cancer among men. (...)
Mots-clés Pascal : Hypernéphrome, Rein, Exercice physique, Facteur risque, Epidémiologie, Etude cohorte, Suède, Europe, Homme, Carcinome, Appareil urinaire pathologie, Rein pathologie, Tumeur maligne
Mots-clés Pascal anglais : Grawitz tumor, Kidney, Physical exercise, Risk factor, Epidemiology, Cohort study, Sweden, Europe, Human, Carcinoma, Urinary system disease, Kidney disease, Malignant tumor
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0490539
Code Inist : 002B14D01. Création : 22/03/2000.