This report describes the background, rationale, and research plan for a comparative treatment trial of the effectiveness of paroxetine, problem-solving therapy (PST-PC), and placebo in the treatment of minor depression and dysthymia in primary care patients.
Patients were recruited from a variety of primary care practice settings in four separate geographic locations (Hanover, New Hampshire ; Pittsburgh, Pennsylvania ; San Antonio, Texas ; and Seattle, Washington).
Patients were randomly assigned to each of the three intervention conditions ; the medication/placebo conditions were double-blinded.
The treatment trial was 11 weeks, with independent assessments of patient clinical status at baseline, 6 weeks, and 11 weeks.
There was a follow-up at 25 weeks.
Since there are relatively few placebo-controlled trials in primary care settings on patients with these disorders, the background of this project and a description of are presented at this time, prior to the availability of outcome data, to provide methodological detail and to increase awareness in the research community of this treatment trial, with results to appear subsequently.
Mots-clés Pascal : Etat dépressif, Dysthymie, Traitement, Programme sanitaire, Evaluation, Efficacité traitement, Paroxétine, Inhibiteur recapture, Sérotonine, Antidépresseur, Psychotrope, Chimiothérapie, Etude comparative, Thérapie comportementale, Résolution problème, Placebo, Soin santé primaire, Homme, Santé mentale, Environnement social, Pipéridine dérivé, Etats Unis, Amérique du Nord, Amérique, Trouble humeur
Mots-clés Pascal anglais : Depression, Dysthymia, Treatment, Sanitary program, Evaluation, Treatment efficiency, Paroxetine, Reuptake inhibitor, Serotonin, Antidepressant agent, Psychotropic, Chemotherapy, Comparative study, Behavior therapy, Problem solving, Placebo, Primary health care, Human, Mental health, Social environment, Piperidine derivatives, United States, North America, America, Mood disorder
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0488258
Code Inist : 002B18I16. Création : 22/03/2000.