This study evaluated the results of surgical and nonsurgical treatments of hepatocellular carcinoma (HCC) in the elderly to determine the optimal management strategy.
Clinicopathological data and treatment results of 222 elderly (>=70 yr) and 1116 younger patients with HCC managed between 1989 and 1997 were prospectively collected and compared between the two groups.
The resection rate in the elderly (14%) was lower than in younger patients (27%) (p<0.001).
Among patients who underwent resection, there were no significant differences in morbidity rate (48% vs 40%, p=0.354), hospital mortality rate (10% vs 6%, p=0.431), or long-term survival (median, 38 vs 42 months, p=0.940).
Comparing the periods 1989-1992 and 1993-1997, hospital mortality rate in the elderly was reduced from 25% to 4% (p=0.079).
Sixty-seven elderly and 317 younger patients underwent transarterial oily chemoembolization (TOCE), with similar morbidity rate (24% vs 26%, p=0.775), mortality rate (7% vs 5%, p=0.365), and long-term survival (median, 12 vs 9 months, p=0.277).
The results of other nonsurgical treatments were also similar between the two groups.
Hepatic resection for HCC is safe in selected elderly patients, and the improved results in recent years indicate that more elderly patients could benefit from surgical management.
TOCE is well tolerated in elderly patients and is the treatment of choice for unresectable HCC. (...)
Mots-clés Pascal : Carcinome hépatocellulaire, Personne âgée, Homme, Stratégie, Chirurgie, Stade clinique, Traitement, Résultat, Article synthèse, Chine, Asie, Appareil digestif pathologie, Foie pathologie, Tumeur maligne
Mots-clés Pascal anglais : Hepatocellular carcinoma, Elderly, Human, Strategy, Surgery, Clinical stage, Treatment, Result, Review, China, Asia, Digestive diseases, Hepatic disease, Malignant tumor
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0487570
Code Inist : 002B25G03. Création : 22/03/2000.