Drug-associated acute pancreatitis : Twenty-one years of spontaneous reporting in the Netherlands.
Drugs are considered a rare cause of acute pancreatitis.
We conducted a descriptive study to assess which drugs have been associated with acute pancreatitis in spontaneous adverse drug reaction reports in the Netherlands.
Our study is based on reports of drug-associated acute pancreatitis reported to the Netherlands Center for Monitoring of Adverse Reactions to Drugs and the Netherlands Pharmacovigilance Foundation LAREB between 1 January 1977 and 1 January 1998.
We used an algorithm to validate the diagnosis and to assess the causal relationship between acute pancreatitis and use of the suspected drug.
A total of 55 cases were available for review.
We excluded 11 (20.0%) reports, as we could not confirm the diagnosis of acute pancreatitis.
Another 10 (18%) cases were excluded, as the causal relationship with the suspected drug was unlikely.
In the remaining 34 reports, acute pancreatitis was labeled as definite in 11 (32%) and as probable in 23 (68%). The age of the patients ranged from 17 to 84 yr with a median of 41 ; 24 (71%) patients were female.
Of the 34 cases, 27 (79%) recovered, five (15%) died, and in two (6%) the outcome is unknown.
Azathioprine, cimetidine, interferon-alpha, methyldopa, metronidazole, olsalazine, and oxyphenbutazon all had a definite causal relationship with acute pancreatitis. (...)
Mots-clés Pascal : Pancréatite, Aigu, Association, Médicament, Effet secondaire, Epidémiologie, Pharmacovigilance, Compte rendu, Spontané, Pays Bas, Europe, Diagnostic, Appareil digestif pathologie, Pancréas pathologie
Mots-clés Pascal anglais : Pancreatitis, Acute, Association, Drug, Secondary effect, Epidemiology, Pharmacovigilance, Report, Spontaneous, Netherlands, Europe, Diagnosis, Digestive diseases, Pancreatic disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0487569
Code Inist : 002B02U04. Création : 22/03/2000.