A case-control study of stomach cancer which includes 448 cases and 610 hospital controls has been conducted in Moscow, Russia.
Information on life-style habits, such as smoking, alcohol consumption, diet, medical history and use of different medications including aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) was collected using a self-administered structured questionnaire.
Venous blood was drawn from 361 cases and 441 controls.
A serological test for Helicobacter pylon immunoglobulin G was performed to detect infected individuals.
Use of aspirin and other NSAIDs was associated with protection against cancer of the stomach (OR=0.60,95% Cl 0.41-0.90).
Analysis by subsite revealed that aspirin did not affect the risk of cancer of the gastric cardia but had a protective effect for non-cardia gastric cancer.
The OR associated with use of aspirin adjusted for age and education for both sexes combined was 0.49 (95% Cl 0.31-0.77).
A decrease in relative risk was statistically significant for men (OR=0.48,95% Cl 0.25-0.92) and women (OR=0.52,95% Cl 0.28-0.97).
Controlling for major risk factors did not attenuate the reduction in risk.
The observed associations were also present in individuals who were H. pylori immunoglobulin G-positive.
There was no reduction in risk associated with aspirin andlor non-aspirin NSAIDs among non-infected subjects.
Mots-clés Pascal : Tumeur maligne, Estomac, Antiinflammatoire non stéroïde, Acétylsalicylique acide, Facteur risque, Epidémiologie, Prévention, Chimioprophylaxie, Anticarcinogène, Russie, Eurasie, Homme, Salicylés, Appareil digestif pathologie, Estomac pathologie
Mots-clés Pascal anglais : Malignant tumor, Stomach, Non steroidal antiinflammatory agent, Acetylsalicylic acid, Risk factor, Epidemiology, Prevention, Chemoprophylaxis, Anticarcinogen, Russia, Eurasia, Human, Salicylates, Digestive diseases, Gastric disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0487135
Code Inist : 002B04E02. Création : 22/03/2000.