We aimed to examine birthweight, low birthweight (<2500 g), and intrauterine growth retardation in offspring of women with celiac disease in relation to their first hospitalization for the disease.
This was a historical cohort study based on The Danish Medical Birth Registry data of celiac women discharged from Danish hospitals from 1977-1992.
The study included 211 newborns to 127 mothers with celiac disease, and 1260 control deliveries.
Before celiac women were first hospitalized the mean birthweight of their newborns was 238 g (95% confidence interval [95% CI]=150,325 g) lower than that of the control women, after adjustment for potential confounders.
After the first hospitalization the mean birthweight for newborns of diseased women was higher than that of controls, by 67 g (95% CI=-88,223 g) after adjustment for potential confounders.
Before celiac women were first hospitalized we found an increased risk of low birthweight (odds ratio [OR]=2.6,95% CI=1.3-5.5) and intrauterine growth retardation (OR=3.4,95% CI=1.6-7.2).
After celiac women were first hospitalized we found no increased risk of low birthweight and no babies with intrauterine growth retardation.
Offspring of mothers with celiac disease had lower birthweight than expected and more than a threefold higher risk of intrauterine growth retardation when birth occurred before the first hospitalization for the disease. (...)
Mots-clés Pascal : Coeliaque maladie, Etude cohorte, Historique, Poids naissance, Poids naissance faible, Retard staturopondéral, Gestation, Facteur risque, Descendance, Résultat, Femelle, Danemark, Europe, Analyse statistique, Appareil digestif pathologie, Intestin pathologie, Malabsorption intestinale, Immunopathologie, Pédiatrie, Appareil génital femelle
Mots-clés Pascal anglais : Coeliac disease, Cohort study, Case history, Birth weight, Low birth weight, Growth retardation, Pregnancy, Risk factor, Progeny, Result, Female, Denmark, Europe, Statistical analysis, Digestive diseases, Intestinal disease, Intestinal malabsorption, Immunopathology, Pediatrics, Female genital system
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0486842
Code Inist : 002B13B03. Création : 22/03/2000.