To examine the incidence and clinical features of adults with biopsy proven cutaneous vasculitis (CV) associated with drugs.
Retrospective study of an unselected population of adults (age>20 years) with biopsy proven leukocytoclastic CV from 1988 through 1997.
Drug associated CV was considered if CV was confirmed by a skin biopsy and there was a history of drug use within one week before the development of CV.
Drug associated CV was classified by American College of Rheumatology (ACR) criteria.
To differentiate Henoch-Schönlein purpura (HSP) from hypersensitivity vasculitis (HV), the traditional criteria proposed by Michel, et al were used (J Rheumatol 1992 ; 19 : 721-8).
Thirty-three of 138 patients (23.9%) presenting with biopsy proven CV were diagnosed with drug associated CV.
The annual incidence rate of biopsy proven drug associated CV in adults was 17.49 cases/million (95% CI 11.53-23.46) : men 25.10/million (95% Cl 14.85-35.36), women 10.31/million (95% Cl 3.92-16.70).
Antibiotics (n=13), especially amoxicillin, and analgesics or nonsteroidal antiinflammatory drugs (n=11) were the drugs more commonly associated with CV.
All adults with drug associated CV met the ACR classification criteria for HV or HSP.
Based on Michel's criteria 26 patients (78.8%) were classified as having HV and 7 HSP.
No patient met ACR criteria for other systemic vasculitides.
Complete recovery with no sequelae was observed in most cases.
Mots-clés Pascal : Vascularite, Peau, Association, Toxicité, Médicament, Symptomatologie, Epidémiologie, Incidence, Adulte, Homme, Purpura rhumatoïde, Espagne, Europe, Appareil circulatoire pathologie, Vaisseau sanguin pathologie, Immunopathologie, Peau pathologie, Capillaire sanguin pathologie, Système ostéoarticulaire pathologie
Mots-clés Pascal anglais : Vasculitis, Skin, Association, Toxicity, Drug, Symptomatology, Epidemiology, Incidence, Adult, Human, Henoch-Schönlein purpura, Spain, Europe, Cardiovascular disease, Vascular disease, Immunopathology, Skin disease, Capillary vessel disease, Diseases of the osteoarticular system
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0486718
Code Inist : 002B02U10. Création : 22/03/2000.