Etiology and outcome of chronic renal failure in Indian children.
A prospective analysis of all new pediatric cases of chronic renal failure (CRF) was performed at our hospital over a 1-year period.
The diagnosis of CRF was based on serum creatinine>2 mg/dl with supportive clinical, laboratory, and radiological findings.
There were a total of 48 patients with CRF with a median age of 13 years (range 10 days to 16 years).
The causes of CRF included glomerulonephritis (37.5%), obstruction and interstitial (52%). hereditary (6.3%), and undetermined (4.2%). Patients were symptomatic for a mean of 33.2 months (range 10 days to 11 years) at presentation.
Eight patients (16.7%) had acute reversible deterioration of renal function at presentation.
This was due to accelerated hypertension in 2, infection in 3, volume depletion in 2, and nonsteroidal antiinflammatory drugs in 1 patient.
At presentation, 22 (46%) children had mild to moderate renal failure and 26 (54%) had end-stage renal disease.
Twenty-one children (43.7%) had associated illness at presentation.
Mean follow-up was 22.9 weeks (range 2-126 weeks).
At the end of the study period, 10 (21%) patients were on conservative treatment, 7 (14.6%) on maintenance dialysis, 8 (16.7%) patients had functioning allografts, 4 (8.3%) patients had died, and 19 (39.6%) opted against further therapy.
We conclude that CRF in Indian children carries a poor prognosis due to late referral and the limited availability and high cost of renal replacement therapy.
Mots-clés Pascal : Insuffisance rénale, Chronique, Hémodialyse, Homotransplantation, Rein, Néphropathie glomérulaire, Indien, Etiologie, Traitement, Pronostic, Enfant, Homme, Appareil urinaire pathologie, Rein pathologie, Epuration extrarénale, Transplantation, Chirurgie
Mots-clés Pascal anglais : Renal failure, Chronic, Hemodialysis, Homotransplantation, Kidney, Glomerulonephritis, Indian, Etiology, Treatment, Prognosis, Child, Human, Urinary system disease, Kidney disease, Extrarenal dialysis, Transplantation, Surgery
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0485403
Code Inist : 002B14A05. Création : 22/03/2000.